Guangbin Dong Professor of Chemistry

Professor of Chemistry, University of Chicago, 2016-
Professor of Chemistry, Pettit Centennial Chair (declined), University of Texas at Austin, 2016
Assistant Professor, CPRIT Scholar for Cancer Research, University of Texas at Austin, 2011 – 2016
Camille and Henry Dreyfus Postdoctoral Fellow, California Institute of Technology, 2009 – 2011
Ph.D. in Chemistry, Stanford University, Stanford, California, 2004 – 2009
B.S. in Chemistry, Peking University, Beijing, China, 1999 – 2003

Accolades

American Cancer Society Research Scholar (2014)
Amgen Young Investigators’ Award (2014)
Dupont Young Professor Program Award (2014)
Teaching Excellent Award, UT Austin (2014)
CAPA Biomatik Distinguished Junior Faculty Award
Sloan Research Fellow (2014)
Searle Scholar (2013)
National Science Foundation CAREER Award
Thieme Synlett/Synthesis Journal Award (2012)
Ralph E. Powe Junior Faculty Enhancement Awards
Herman Frasch Award in Chemical Research
CPRIT Award for Recruitment First-Time Tenure-Track Faculty Member (2011-2015)
IUPAC Prizes for Young Chemists (2010)
Reaxys PhD Prize, Runners-up, Elsevier (2010)
Camille and Henry Dreyfus Environmental Chemistry Fellow (2009)

E-MAIL: gbdong@uchicago.edu

WEB: http://donggroup-sites.uchicago.edu

RESEARCH INTERESTS:

Our research focuses on 1) developing new transition metal catalysts based on supermolecular chemistry for chemoselective C-H bond activation of small molecules; 2) developing novel catalytic C-H and C-C bond activation methods for efficient small-molecule agents synthesis; 3) establishing efficient synthetic routes to access natural products with high potent anticancer activity and their unnatural analogues; and 4) evaluating in vitro and in vivo efficacy of rationally designed natural product analogues and understanding the origins of the selectivity in the cell-killing process; 5) developing new methods for preparation of novel graphene nanoribbon materials from a bottom-up approach.

 

References:

Zhou, Xuan; Dong, Guangbin* “(4+1) vs (4+2): Catalytic Intramolecular Coupling between Cyclobutanones and Trisubstituted Allenes via C−C Activation” J. Am. Chem. Soc., 2015, 137, 13715-13721.

Lim, Hee Nam; Dong, Guangbin* “Catalytic Intramolecular Ketone Alkylation with Olefins via Dual Activation” Angew. Chem. Int. Ed. 2015, 54, 15294-15298.

Xu, Yan; Yan, Guobing; Ren, Zhi; Dong, Guangbin* “A Unified Strategy for Diverse Functionalization at Alcohol β-Position” Nature Chemistry, 2015, 7, 829-834.

Thompson, Samuel J.; Thach, Danny Q.; Dong, Guangbin* “Cyclic Ether Synthesis via Palladium-catalyzed Alcohol-mediated Dehydrogenative Annulation at Unactivated Terminal Positions” J. Am. Chem. Soc., 2015, 137, 11586-11589.

Ko, Haye Min; Dong, Guangbin* “Cooperative activation of cyclobutanones and olefins leads to bridged-ring systems by a catalytic [4+2] coupling” Nature Chemistry, 2014, 6, 739-744.

Mo, Fanyang; Dong, Guangbin* “Regioselective Ketone α-Alkylation with Simple Olefins via Dual Activation”, Science, 2014, 345, 68–72.

Dong, Zhe; Dong, Guangbin* “Ortho vs Ipso: Site-Selective Pd and Norbornene-Catalyzed Arene C–H Amination Using Aryl Halides” J. Am. Chem. Soc., 2013, 135, 18350-18353.

Huang, Zhongxing; Dong, Guangbin* “Pd-Catalyzed Direct β–Arylation of Simple Ketones with Aryl Halides” Journal of the American Chemical Society, 2013, 135, 17747-17750.

Xu, Tao; Dong, Guangbin* “Rh-Catalyzed Lewis Acid-Promoted Regioselective Carboacylation of Olefins: A C–C Activation Approach to Access Fused-Ring Systems” Angew. Chem. Int. Ed., 2012, 51, 7567–7571.

Ren, Zhi; Mo, Fanyang; Dong, Guangbin* “Catalytic Functionalization of Unactivated sp3 C–H Bonds via exo-Directing Group: Synthesis of Chemically Differentiated 1,2-Diols” J. Am. Chem. Soc., 2012, 134, 16991-16994.